Growth Factors, Hormones and Cellular Genes in Neoplasia

Although structurally altered genes, categorized as oncogenes or cancer suppressor genes, are essential mediators of cancer, the role of unaltered genes is not to be dismissed and it is probably equally crucial in carcinogenesis. Signaling proteins of all kinds may possibly drive the oncogenic procedure through abnormal signaling: abnormal in time, duration, or intensity; abnormal tissue appearance; or abnormal subcellular compartment localization. The regulation of development in complex organisms demands specific proteins for the usual development, maturation, improvement, and function of tissue and specialized structure.